Potassium Iodide BP USP IP ACS Reagent FCC Food Grade

Anmol Chemicals is the pioneer manufacturers of Potassium iodide, Pharmaceutical Excipients Food & Flavor chemicals in India. We offer Halal and Kosher Potassium iodide made in an ISO9001, ISO22000 (FSSC22000) cGMP and GLP certified facility. Our group has several manufacturing facilities spread across the world, supported by toll manufacturers and representatives in UAE, Europe, USA, China and has several associated manufacturing facilities spread across India. All the Information on Physics, Chemistry, Applications, Uses and Technology on Manufacture of Potassium iodide is in these pages.

The units have one or more of the certifications like FDA GMP, ISO 9001, ISO 22000, HACCP, REACH, Kosher & Halal

Potassium Iodide USP BP IP Analytical Reagent ACS FCC Food Grade Manufacturers

Potassium Iodide CAS Number 7681-11-0, Molecular Weight 166, Chemical Formula: KI

Potassium Iodide contains not less than 99.0 percent and not more than 101.5 percent of KI, calculated on the dried basis.

Identification: A solution of it meets the requirements of the tests for Potassium and for Iodide.
Alkalinity: Dissolve 1.0 g in 10 mL of water, and add 0.1 mL of 0.1 N sulfuric acid and 1 drop of phenolphthalein TS: no color is produced.
Loss on drying: Dry it at 105C for 4 hours: it loses not more than 1.0% of its weight.
Iodate: Dissolve 1.1 g in sufficient ammonia- and carbon dioxide-free water to obtain 10 mL of solution, and transfer to a color-comparison tube. Add 1 mL of starch TS and 0.25 mL of 1.0 N sulfuric acid, mix, and compare the color with that of a control containing, in a similar volume, 100 mg of Potassium Iodide, 1 mL of standard iodate solution [prepare by diluting 1 mL of potassium iodate solution (1 in 2500) with water to 100 mL], 1 mL of starch TS, and 0.25 mL of 1.0 N sulfuric acid. Any color produced in the solution of the test specimen does not exceed that in the control: not more than 4 µg per g is found.
Limit of nitrate, nitrite, and ammonia: To a solution of 1 g in 5 mL of water contained in a test tube of about 40-mL capacity add 5 mL of 1 N sodium hydroxide and about 200 mg of aluminum wire. Insert a pledget of purified cotton in the upper portion of the test tube, and place a piece of moistened red litmus paper over the mouth of the tube. Heat the test tube and its contents in a steam bath for 15 minutes: no blue coloration of the paper is discernible.
Thiosulfate and barium: Dissolve 0.5 g in 10 mL of ammonia- and carbon dioxide-free water, and add 2 drops of 2 N sulfuric acid: no turbidity develops within 1 minute.
Heavy metals: Dissolve 2.0 g in 25 mL of water: the limit is 0.001%.
Assay: Dissolve about 500 mg of Potassium Iodide, accurately weighed, in about 10 mL of water, and add 35 mL of hydrochloric acid. Titrate with 0.05 M potassium iodate VS until the dark brown solution which is produced becomes pale brown. Add 2 to 3 drops of amaranth TS, and continue the titration slowly until the red color just changes to yellow. Each mL of 0.05 M potassium iodate is equivalent to 16.60 mg of KI.

Potassium Iodide BP Grade Ph Eur
Content: 99.0 per cent to 100.5 per cent (dried substance).

CHARACTERS
Appearance: White or almost white powder or colourless crystals.
Solubility: Very soluble in water, freely soluble in glycerol, soluble in ethanol (96 per cent).

IDENTIFICATION
A. Solution S (see Tests) gives the reactions of iodides (2.3.1).
B. Solution S gives the reactions of potassium (2.3.1).

TESTS
Solution S: Dissolve 10.0 g in carbon dioxide-free water R prepared from distilled water R and dilute to 100 ml with the same solvent.
Appearance of solution: Solution S is clear and colourless.
Alkalinity: To 12.5 ml of solution S add 0.1 ml of bromo-thymol blue solution R1. Not more than 0.5 ml of 0.01 M hydrochloric acid is required to change the colour of the indicator.
Iodates: To 10 ml of solution S add 0.25 ml of iodide-free starch solution R and 0.2 ml of dilute sulphuric acid R and allow to stand protected from light for 2 min. No blue colour develops.
Sulphates: Maximum 150 ppm.
Dilute 10 ml of solution S to 15 ml with distilled water R.
Thiosulphates: To 10 ml of solution S add 0.1 ml of starch solution R and 0.1 ml of 0.005 M iodine. A blue colour is produced.
Iron: Maximum 20 ppm.
Dilute 5 ml of solution S to 10 ml with water R.
Heavy metals: Maximum 10 ppm.
12 ml of solution S complies with test A. Prepare the reference solution using lead standard solution (1 ppm Pb) R.
Loss on drying: Maximum 1.0 per cent, determined on 1.00 g of previously powdered substance by drying in an oven at 105 °C for 3 h.

ASSAY
Dissolve 1.500 g in water R and dilute to 100.0 ml with the same solvent. To 20.0 ml of the solution add 40 ml of hydrochloric acid R and titrate with 0.05 M potassium iodate until the colour changes from red to yellow. Add 5 ml of chloroform R and continue the titration, shaking vigorously, until the chloroform layer is decolourised.
1 ml of 0.05 M potassium iodate is equivalent to 16.60 mg of KI.

Category: Antithyroid; antifungal; expectorant.
Description: Colourless crystals or white powder; odourless
Solubility: Very soluble in water; freely soluble in glycerin; soluble in ethanol (95%).

STANDARDS
Potassium Iodide contains not less than 99.0 per cent and not more than 100.5 per cent of KI, calculated with reference to the dried substance.
Identification: A 10% w/v solution in carbon dioxide-free water (solution A) gives the reactions of potassium salts and of iodides.
Alkalinity: To 10 ml of solution A add 0.2 ml of 0.01M sulphuric acid; no colour is produced on addition of a drop of phenolphthalein solution. .
Clarity and colour of solution: Solution A is clear and colourless.
Arsenic: Dissolve 5.0 g in 50 ml of 'water and 12 ml of stannated hydrochloric acid AsT. The resulting solution complies with the limit test for arsenic (2 ppm).
Heavy metals: Not more than 10 ppm, determined on 2.0 g
Iron: Solution A complies with the limit lest for iron (20 ppm).
Barium: Dissolve 0.5 g in 10 ml of water and add 1 ml of dilute sulphuric acid; no turbidity develops within one minute.

DESCRIPTION
Potassium Iodide occurs as hexahedral crystals, either transparent and colorless or somewhat opaque and white, or as a white, granular powder. It is stable in dry air but slightly hygroscopic in moist air. One gram is soluble in 0.7 mL of water at 25°, in 0.5 mL of boiling water, in 2 mL of glycerin, and in 22 mL of alcohol.

REQUIREMENTS
Identification:
A. A 1:10 aqueous solution responds to the tests for Potassium and for Iodide.
B. The pH of a 1:20 aqueous solution is between 6 and 10.
Assay: Not less than 99.0% and not more than 101.5% of KI after drying.
Iodate: Not more than 4 mg/kg.
Lead: Not more than 4 mg/kg.
Loss on Drying: Not more than 1%.
Nitrate, Nitrite, and Ammonia: Passes test.
Thiosulfate and Barium: Passes test.

TESTS
Assay: Dissolve about 500 mg of sample, previously dried at 105° for 4 h and accurately weighed, in about 10 mL of water, and add 35 mL of hydrochloric acid and 5 mL of chloroform. Titrate with 0.05 M potassium iodate until the purple color of iodine disappears from the chloroform. Add the last portions of the iodate solution drop-wise, agitating vigorously and continuously. After the chloroform is decolorized, allow the mixture to stand for 5 min. If the chloroform develops a purple color, titrate further with the iodate solution.
Each milliliter of 0.05 M potassium iodate used is equivalent to 16.60 mg of KI.
Iodate: Dissolve 1.1 g of sample in sufficient ammonia- and carbon dioxide-free water to make 10 mL of solution, and transfer to a color-comparison tube. Add 1 mL of starch TS and 0.25 mL of 1 N sulfuric acid, mix, and compare the color with that of a control containing, in each 10 mL, 100 mg of Potassium Iodide, 1 mL of standard iodate solution (prepared by diluting 1 mL of a 1:2500 solution of potassium iodate to 100 mL with water), 1 mL of starch TS, and 0.25 mL of 1N sulfuric acid. Any color in the sample solution does not exceed that in the control.
Lead: Determine as directed in the Flame Atomic Absorption Spectro-photometric Method under Lead Limit Test, using a 10-g sample.
Loss on Drying: Determine as directed under Loss on Drying, drying a sample at 105° for 4 h.
Nitrate, Nitrite, and Ammonia: Dissolve 1 g of sample in 5 mL of water in a 40-mL test tube, and add 5 mL of 1 N sodium hydroxide and about 200 mg of aluminum wire. Insert a cotton plug in the upper portion of the tube, and place a piece of moistened red litmus paper over the mouth of the tube. Heat in a steam bath for about 15 min. No blue coloration of the paper is discernible.
Thiosulfate and Barium: Dissolve 500 mg of sample in 10 mL of ammonia- and carbon dioxide-free water, and add 2 drops of diluted sulfuric acid. No turbidity develops within 1 min.

MAXIMUM ALLOWABLE
Insoluble matter: 0.005%
Loss on drying at 150C: 0.2%
Chloride and bromide (as Cl): 0.01%
Iodate (IO3): 3 ppm
Nitrogen compounds (as N): 0.001%
Phosphate (PO4): 0.001%
Sulfate (SO4): 0.005%
Barium (Ba): 0.002%
Heavy metals (as Pb): 5 ppm
Iron (Fe): 3 ppm
Calcium (Ca): 0.002%
Magnesium (Mg): 0.001%
Sodium (Na): 0.005%

Pure Potassium Iodide Manufacturers IP BP USP ACS FCC Food Grade:

Anmol Chemicals
S-8, SARIFA MANSION, 2ND FLANK ROAD, CHINCHBUNDER, MUMBAI 400009, INDIA
TEL: (OFFICE) 91-22-23770100, 23726950, 23774610, 23723564 - FAX: 91-22-23728264

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